Professor Tsai has helped the establishment of genome research facility at the National Yang-Ming University and the National Health Research Institutes. His team has pioneered in Taiwan the whole-genome sequencing of a biological organism and championed in genomic studies of Vibrio vulnificus and Klebsiella pneumoniae. He has led the successful identification of two Col2A1 gene variants responsible for the autosomal dominant form of osteonecrosis of the femoral head. His team also discovered high frequency and complex pattern of the Epidermal Growth Factor Receptor gene mutation in adenocarcinoma of the lung in Taiwanese patients and conducted de novo sequencing and SNP discovery projects for the chromosome 4q region implicated in hepatocellular carcinoma oncogenesis. Professor Tsai has authored more than 100 peer-reviewed papers in the fields of genetics and genomics.